【摘要】 本文对36例冠心病患者在做经皮冠状动脉腔内成形术(PTCA)前后进行了对比研究,发现PTCA术后左心室前壁增厚率(PVWTA)和左心室后壁增厚率(PVWTP)比术前显著下降(P<0.05)提示PTCA术后发生了心肌顿抑现象.并且,术后外周静脉血SOD活性比术前显著下降(P<0.01),MDA含量显著地升高(P<0.001),术后心肌酶比术前显著升高(P<0.01),提示PTCA术后心肌顿抑与异常自由基反应损害心肌细胞有关.更多还原

【Abstract】 The myocardial stunning following percutaneous transluminal coronary angioplasty (PTCA) were studied in 36 patients with coronary heart disease. Results Indicated that the percentages of ventricular wall thickness of anterior wall (PVWTA)and the percentages of ventricular wall thickness of posterior wall (PVWTP) were significantly decreased (P<0.05) after PTCA. The results indicated that there were myocardial stunning changes in patients treated with PTCA. In vein blood, SOD (superoxide dismutase) activities were significantly decreased (P<0.001), MDA(malondialdehyde) contents were singificantly increased (P<0.001) after PTCA. cardiac enzymes were significantly increased (P<0.01) after PTCA. The results suggest stunning myocardium might aggravate the abnormal free radical reactions which injured myocardium.更多还原