【摘要】 探索利用冷冻处理异体硬脑膜引导种植体周围骨组织再生的可能性。12只日本大耳白兔 ,在双侧下颌下缘造成骨缺损 ,右侧覆盖兔冷冻异体硬脑膜 ,左侧不覆膜 ;临床用于种植体周围骨缺损24例 ,采用人异体冷冻硬脑覆盖。结果实验动物伤口均I期愈合。组织学观察实验侧4周时骨表面有柱状骨突起 ,18周改建为成熟骨 ;对照侧明显慢于实验侧。临床患者骨修复良好 ,其中15例(16区)裂隙状骨缺损修复率达87.8 %。冷冻异体硬脑膜是一种较理想的引导骨组织再生膜材料更多还原

【Abstract】 Objective investigating the feasibility of guiding bone tissue regeneration used by the frozen allogeneis duramater around implants. In experiment artificial bone defects in bilateral lower border of mandible were performed in 12 white Japanse big ear rabbits. The right defects were covered with the membrances, and the left defects not covered membrances as contral. In clinic the authors utilized the frozen human allogeneis dura mater to guide bone tissue regeneration to restore defects around implants in 24 patients. The wounds of all animals healed by first intention. The histological observations showed appearence of pillar like bone towers on the surface of bone in the experiment sides at the fourth week, and mature bone at the eighteenth week. The bone restorations in contorlled side . The restorations of bone defects of all patients were high successful clinically.15 cases of patients with fissure-like bone defects had high repairing rate up to 87.7%. The frozen allo-dura mater is an ideal material guiding bone tissue regeneration更多还原