【摘要】 目的:探讨肌上皮细胞(MC)和基底膜(BM)在乳腺乳头状病变中的分布情况。方法:用单克隆抗体HHF35(抗肌动蛋白)和抗Co11 Ⅳ(抗四型胶原)对42例乳头状病变进行免疫组化(ABC法)标记。结果:1.导管内乳头状瘤和乳头状瘤病的导管周多有较连续的MC和BM分布,而在乳头状结构中前者亦有MC和BM分布,而后者却无;2.乳头状导管内癌导管周可有也可无MC和BM,若无可能预示着肿瘤浸润的开始,而乳头状癌既无MC,也无BM表达;3.良恶性病变中MC和BM的表达在统计学上有非常显著性差异(x~2检验,P<0.0005)。结论:MC和BM标记对乳腺乳头状病变的诊断和鉴别诊断有重要的参考价值。更多还原

【Abstract】 Objectives:To study the distribution of myoepithelial cells ( MC) and basement membrane (BM) in breast. Method: 42 papillary lesions of the human breast were collected for investigation of MC and BM by immunohistochemical method with HHF35 (monoclonal antibody against muscle actin) and monoclonal antibody against type Ⅳcollagen. Results: 1. MC and BM were continuous at the periphery of ducts in intraductal papilloma and papillomatosis, but in papillary architecture, former MC and BM existed and later were absent. 2. MC and BM may be present of cacinoma was presupposed or absent in papillary intraductal carcinoma, if MC and BM diasppeared invasion to occur,but in papillary carcinoma,there were neither MC nor BM.3.MC and BM always existed in benign lesions and disappered in malignant lesions, there were statistical signifinant difference between benign and malignant lesion. Conclusion: MC and BM give valuable information in differential diagnosis in papillary lesions of the breast.更多还原