【摘要】 为了探讨脂蛋白脂肪酶基因内含子6区（PvuⅡ）和8区（HindⅢ）位点变异与冠心病的关系，应用聚合酶链反应一限制性片段长度多态性方法分析106例心肌梗塞存活病人及106例正常健康人的脂蛋白脂肪酶基因PvuⅡ、HindⅢ位点多态性。并采用非条件的lo-gistic单元及多元回归分析。结果发现，糖尿病史、吸烟史、高血压、脂蛋白脂肪酶等位基因P-和单倍体H+P-是冠心病独立的危险因素，其中P-和H+P-在多元回归分析后其比值比为3．59和2.54，载脂蛋白A／B的比值比为0．06。因此认为除传统的危险因素外，脂蛋白脂肪酶P-和单倍体H+P-也是冠心病独立的危险因素，载脂蛋白A／B比值可能是较其他血脂指标更好的冠心病独立的预测危险因素。更多还原

【Abstract】 Aim Whether the mutation of lipoprotein lipase (LPL) gene is associated with coronary heart disease (CHD) or not has been yet knon We study rela-tionship between mutation in intro 6(PvuⅡ) and 8region of LPL gene and CHDMethods We analysed 106 patients in myocardial infarction survivors through a case-control study.The technique of lpoymerase chain reaction (PCR)-re-striction fragment lengths polymorphism(RFLP)was useh to analysed the genotype of LPL gene.23 fac-tors maybe involved in CHD was chosed. Simple and multiple non-conditioned logistic regression analysis demostrated that 6factors were association with CHD.Results The risk factors were diabetes, smoke,hypertension,LPL GENOTYPE pvu ⅡP P and haplo-type H+ P-. While Apo A/B ratio was regarded as a protective factor.Conclusion LPL genotype Pvu P-P- or H+P- oth-er than the standard risks was contribuing to CHD.更多还原