【摘要】 为研究冠心病患者血管紧张素转换酶（ACE）基因插入／缺失（I／D）多态性分布及其与血清ACE水平的相关性，应用多聚酶链反应方法测定了61例冠心病患者和63例健康人群的ACE基因I／D多态性，并采用微量比色法测定其血清ACE水平。结果发现，冠心病患者ACE基因DD型出现频率显著高于对照组，且DD基因型者具有较高的血清ACE水平。提示ACE基因I／D多态性与血清ACE水平密切相关，DD型ACE基因可能是中国人冠心病发病的独立危险因子。更多还原

【Abstract】 Aim: To determine angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymoprnhism in patients with coronary heart disease (CHD) and its relation with serum ACE levels.Methods: ACE genotypes of 6l patients with CHD and 63 healthy people were detected by PCR, and their serum ACE levels were concomitantly measured by microcolorimetric assay.Results: The frequency of DD genotype in patients with CHD was significantly higher than that in control group apd patients with DD genotype have higher serum ACE levels.Conclusion: ACE gene polymorphism is closely related to serum ACE level and DD genotype of ACE gene may be the independent risk factor of coronary heart disease in Chinese.更多还原