【摘要】 目的探讨遗传因素与成年型糖尿病之间的关系。方法遗传流行病学研究。结果成年型糖尿病先证者的一级亲属糖尿病患病率为6.14％，远比对照组一级亲属的患病率0.98％高，约为6．27倍，以二项分布模型拟合，发现成年糖尿病分布呈家族聚集现象；用Limintel－Cart法计算其分离比为0．0423，以Falconer氏阈值法估算，成年型糖尿病的遗传度为58．6％。结论成年型糖尿病为多基因遗传性疾病。今后应进一步开展宏观流行病学研究的同时结合微观分子水平分析，对阐明成年型糖尿病因和发病机理，以及有效防治极为重要。更多还原

【Abstract】 Objective To explore the relationship between genetic factors and adult-onset diabetes. Methods We applied genetic epidemiological study. Results The prevalence rate of the firstdegree relatives in cases was 6.14%, significantly higher than that noticed in controls (0. 98%). Binominal distribution model showed that adult-onset diabetes had aggregation in families. Using limintel-cart the segregation ratio was 0.0423, estimated by Falconer threshold model, the heritability was 58.6%. Conclusions Adult-onset diabetes is one of the polygenic disease. Further progress should be made by combining cellular level analysis with epidemiological study. Such is very important to illustrate the etiology and mechanism of adult-onset diabetes and to improve the prevention and therapeutics.更多还原