【摘要】 为观察模拟失重和辐射对心肌细胞代谢的影响，用回转器模拟失重和６０Ｃｏ－γ射线辐照为手段，观察了模拟失重和辐照对大鼠心肌细胞代谢的影响。结果表明，２Ｇｙ６０Ｃｏ－γ射线辐照对培养心肌细胞的超氧化物歧化酶（ＳＯＤ）含量和乳酸脱氢酶（ＬＤＨ）活性有较显著的影响，丙二醛（ＭＤＡ）含量也都升高。实验组ＬＤＨ活性升高，第３天时比对照组升高６０％，而ＳＯＤ含量在辐照第１天时是对照组的两倍，反映了辐照后细胞的应激反应。特别是辐照和模拟失重共同作用时，呈现一定的协同作用。而２Ｇｙ６０Ｇｏ－γ射线对心肌细胞的辐照作用，在经过一定时间后，是可以恢复到正常水平的。更多还原

【Abstract】 To investigate the changes of the metabolism of rat myocardiac cells cultured in vitro under simulated weightlessness and γ-irradiation, rat myocardiac cells were rotated on a horizontal clinostat,and irradiated with 2Gy ⁶⁰Coγ-ray.The results showed:（1）after irradiation, the LDH activity and SOD concentrations showed a significant increase,and the MDA concentration also increased.（2）After irradiation,LDH activity increased 60% on the 3rd day,and SOD concentration almost doubled on the first day.（2）MDA concentration also increased but it reduced to normal after the 3rd day.（3）Simple rotation on the clinostat showed no effect on the parameter,but there was a synergistic effect when it was combined with γ-irradiation.更多还原