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栉孔扇贝糖蛋白的制备及其抗肿瘤活性初步研究

PRELIMINARY STUDIES ON THE ANTI-TUMOUR ACTIVITY OF GLYCOPROTEIN FROM Chlamys farreri

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【作者】 顾谦群; 王长云; 方玉春; 仲娜;

【Author】 GU Qian qun WANG Chang yun FANG Yu chun ZHONG Na(Marine Drugs and Foods Institute, Ocean University of Qingdao, 266003)

【机构】 青岛海洋大学海洋药物与食品研究所!266003;

【Abstract】 A Glycoprotein was prepared from the skirt of Chlamys farreri by extraction with hot water, isolation and purifi cation with column chromatography on DEAE cellulose and Sephadex G 100 successively. The content of protein and total sugar of the glycoprotein were 60 % and 36 % respectively. Phamarcological tests showed that the glycoprotein could obviously inhibit Sarcoma 180 neoplastic proliferation mice with the inhibition rate of 47.29 %.

【关键词】 栉孔扇贝; 糖蛋白; 抗肿瘤活性;
【Key words】 Chlamys farreri; Glycoprotein; Antitumour activity;
  • 【分类号】R285
  • 【被引频次】36
  • 【下载频次】189
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