【摘要】 目的：观察磁性抗癌微球的自然累积释药速率及局部注射后在血管、组织内的分布、滞留情况。方法：紫外分光光度计测定、分析天平称量。结果：微球溶液在３７℃恒温中放置１２ｈ、２４ｈ、４８ｈ、９６ｈ的自然累积释药速率分别为５２７％、６７２％、７２９％、７４４％；体外实验：在４０００ＧＳ磁场中，流速为每分１０ｃｍ、２０ｃｍ、６０ｃｍ、９０ｃｍ时，微球滞留率分别为９８％、８７％、４１％、２９％；体内实验：局部注射抗癌微球后，在体外磁场作用下，局部血管，组织内微球滞留量明显增多。结论：磁性抗癌微球局注后，在体外磁场作用下，可较长时间滞留于局部缓释抗癌药物。更多还原

【Abstract】 Objective: Observation on the speed rate of natural accumulation and releasing drugs of the magnetic anti-cancer microsphere and the condition of distribution and retention in blood vessels and tissues after being locally injected. Methods: It was measured with ultraviolet spectrophotometry and weighed by analytical balance. Results:The microspherical solution placed at a normal temperature 37℃ for about 12 h,24 h,48 h,96 h,the speed rate of natural accumulation and releasing drugs was 52.7%,67.2%,72.9%,74.4% respectively. Experiment on the outside body: when the speed of flow was 10 cm,20 cm,60 cm,90 cm,per minute, the retention rate of the magnetic microsphere was 98%,87%,41%,29% respectively. Experiment within the body:after the magnetic anti-cancer microsphere being locally injected, under the effect on magnetic field outside the body, the retention rate of the magnetic microsphere increased remarkably in blood vessels and tissues.Conclusion: Under the effect on magnetic field outside the body,the magnetic microsphere was retained in the local part for a long time, slowly releasing anti-cancer drugs.更多还原