【摘要】 目的：观察大鼠糖尿病早期对头孢噻肟（ＣＴＸ）药代动力学的影响。方法：用四氧嘧啶制做大鼠糖尿病模型，高压液相（ＨＰＬＣ）方法测定ＣＴＸ的血药浓度，计算机计算各项药代参数。结果：糖尿病组动物的血药峰浓度和ＡＵＣ值明显低于对照组，但两组的吸收和消除半衰期没有明显差别。结论：提示在糖尿病早期不影响ＣＴＸ的吸收，而消除半衰期没有改变可能与在糖尿病状态下大鼠肝药酶活性降低和肾小球滤过率增加有关。更多还原

【Abstract】 Objective: Observed the pharmacokinetics of cefotaxime (CTX) in early diabetic rats in vivo.Methods: The experimental diabetic male rat models were formed with alloxan.The plasma concentrations of CTX were determined with method of high pressure liquid chromatograph (HPLC).The main pharmacokinetic parameters of two groups were calculated with 3P87 program.Results: Compared with control group,in diabetic group the C(m) and AUC decreased significantly. But the t1/2ka and t1/2ke was not different significantly. Conclusion: It was implied the absorbtion of CTX was not affected in early diabetic rat.It was concerned to the activity hepatic drug enzyme and the glomerular filtration increased in diabetic male rats that the t1/2ke unchanged.更多还原