【摘要】 应用均匀设计，仅做少量实验，然后使用计算机逐步回归出季戊四醇双磷酸酯二磷酰氯的收率与反应条件间的依赖关系：ｙ＝４１．５５８＋４．１３１ｘ３＋０．０７５ｘ１ｘ２－０．８２３ｘ２ｘ３。最优合成条件为：反应温度８１℃，三氯氧磷与季戊四醇的摩尔比３６∶１．０，反应时间２０ｈ。收率８４８％（以季戊四醇计），与预测值接近更多还原

【Abstract】 Based on the experimental data done by means of uniform desigh, a relation between the yield of pentaerythritol bisphosphorate diphosphoryl choloride and the conditions was obtained by the stepwise regression. The optimum conditions of synthesis were chosen as follows: the temperature 81C, molar ratio of phosphorus oxychloride to pentaerythritol 3.6/1.0 and reaction time 20h. The yield of product was 84.8% on pentaerythritol, which was very close to the predict value.更多还原