【摘要】 本研究用免疫组化法检测了食管癌高发区人群中癌前病变、早期癌的抗癌基因p53、癌基因EGFr蛋白的表达和随访研究。结果显示：癌前病变的病人间隔24个月的随访检测表明，无论是阳性或阴性表达，形态学尚未发现有进展为癌的倾向。20例早期食管癌的检测和33～78个月的随访结果显示，肿瘤基因的阳性表达与病人的预后有明显的关系。更多还原

【Abstract】 Expression of p53 and EGFr was assayed immunohistochendcally in esophageal biopsy speCbens obtained ho the high-risk population of esophopal cancer, and a follow - up stUdy was performed. Itwas found that, in the patients either with positive expression of oncogene of with negative expression whosuffered from dysplasia and followed up for 24 months, there are no one developing into esophagus cancer. However, according to the patientS with early esophageal cancer who were followed up for 33 ~ 78months, it is suggested that the expression of p53 protein and EGFr may be a valuable parameter for predichng the prognosis.更多还原