【摘要】 在环境流行病学调查的基础上，用病区粮食及燃煤进行大鼠氟中毒模型的复制，探讨不同类型氟骨症的影响因素及发病机制，为制订有针对性的防治措施提供科学依据。实验表明：除对照组外，其余各组均出现氟斑牙；骨骼Ｘ线摄片及病理组织学检查发现，高氟组出现骨疏松，并伴有骨转换征象，加营养可减轻骨病变程度；呼吸道吸入氟也可引起氟骨症，但病变较轻。引起不同类型氟骨症的主要因素是总摄氟量高、营养低下（蛋白质及钙摄入不足）和铝元素增多等。更多还原

【Abstract】 In order to go further into the influential factors and the pathogenesis of different types of skeletal fluorosis, and provide scientific basis for working out effective measures to prevent and treat fluorosis animal model of fluorosis were induced with food and coal of the endemic area based on the survey of environmental epidemiology before. The results showed that all rats except those of control group had dental fluorosis. Osteoporosis followed abnormal osteo transformation was found in rats of group 1with skeletal roentgenoscopy and pathological diagnosis. The supplementation of nutrition is beneficial to reduce skeletal fluorosis. Fluoride absorbed by respiratory tract can also cause skeletal fluorosis but it was slight. The main effect factors which led up to various types of skeletal fluorosis are total fluoride intake, malnutrition (protein and calcium were absorbed insufficiently) and the element of alnuminium absorbed more, etc.更多还原