【摘要】 比较两种剂量艾司洛尔预防全麻气管插管应激反应的效应。方法：选择全麻择期手术成年患者24例，SAⅠ～Ⅱ级，无明显心血管病史，随机分为两组，Ⅰ组于芬太危3～4μg／kg、咪唑安定0．2mg／kg、卡肌宁0．5mg／kg麻醉诱导后，静注艾司洛尔0．75mg／kg。Ⅱ组：麻醉诱导方法同Ⅰ组，静注艾司洛尔1mg／kg。两组均在艾司洛尔给药3分钟后行气管内插管。观测比较麻醉前，麻醉诱导后，艾司洛尔给药后1分钟、3分钟、置喉镜、气管插管后1、3、5分钟的收缩压、舒张压、平均动脉压及心率变化。结果：Ⅰ组插管后收缩压仍明显高于基础水平，持续至插管后3分钟，Ⅱ组插管后血压及心率变化不明显。结论：以1mg／kg剂量艾司洛尔在小剂量芬太危及咪唑安定诱导后给药能更有效预防气管插管期间应激反应。更多还原

【Abstract】 Objective: To study protective effect of esmolol on Stress response to endotracheal intubation . Methods : 24 casesof patient were randomly divided into two groups. bo was given intruvenously to the two gnupe, after induction with fentanyl3 ~ 4 μg／kg, mindazolam 0.2 mg ／kg and tracrium O.5 mg/kg, group Ⅰwith esmolol 0.75 mg/kg anagnun Ⅱ with esmolol lmg/kg. The parameters of SBP、 DBP、 MAP and HR were compared in groups before induction , after induction , 1min and 3 min after administration of esmolo , laryngendoscope , 1min 3min and 5min after endotracheal intubation. Results : The value of SBPwas significantly increased for 3 minutes after intubation in group Ⅰ, while there was no significant intubation in group Ⅱ　. Con-clusion : It is mare cffective in prevention of strees respond with esmolol 1mg /kg after small doses of fentanyl and midazolam dur-ing period of endotracheal intubation.更多还原