【摘要】 妊娠１２．５ｄ的成年Ｃ５７ＢＬ／６Ｊ小鼠腹腔单次注入氚水，各组仔鼠氚累积吸收剂量分别为０．０３６、０．０７１和０．２１３Ｇｙ。观察氚β射线对仔鼠出生后生长发育及神经行为的影响。结果表明，０．０３６Ｇｙ氚水照射即可使仔鼠体重发育受阻，张耳出现延迟，听觉惊愕发育延迟，痛觉反应潜伏期延长，转体发育延迟，足展开距离增大，Ｙ迷宫刺激单向回避反射逃避时间延长；０．０７１Ｇｙ氚水照射即可使开眼发育延迟，断崖回避、空中翻正出现天龄延迟，连续通道活动转弯数减少，Ｙ迷宫刺激单向回避反射无误率、阳性率降低，条件反射达标率降低；绝大部分指标表现剂量相关。更多还原

【Abstract】 Pregnant adult C57BL/6J mice were randomly assigned to 4 groups and 3 of them were irradiated with beta rays from tritiated water (HTO) by a single intraperitoneal injection on the 12.5th day of gestation.Their offsprings received cumulative dose of 0.036,0.071 and 0.213 Gy,respectively.Offspring of mice were observed for postnatal growth (body weight),the appearance of four physiologic makers (eye opening,pinna detachment,testes decent,viginal opening),the age of acquisition of two reflexes (cloff avoidance,air righting) and sensuous functions (auditory startle,pain threshold),movement and coordination functions and activity (pivoting,foot splay,continuous corridor activity),and learning and memory (electric avoidance reflex in Y maze,conditioning reflex).It was found that results for the parameters in 0.036 or 0.071 Gy group were differed significantly from those for the controls,and for most parameters,a dose dependent effect was found.更多还原