【摘要】 目的：观察结构型一氧化氮合酶在骨关节炎关节软骨及骨唇中的表达及分布，认识结构型一氧化氮合酶在骨关节炎发病机制中的作用。方法：用组织学及原位杂交技术，对临床经过石蜡包埋的骨关节炎关节软骨标本进行定位定性检测。结果：结构型一氧化氮合酶在骨关节炎软骨及骨唇标本中广泛表达。结论：结构型一氧化氮合酶在骨关节炎的发病机制中起重要作用更多还原

【Abstract】 Objective:To investigate the expression and localization of constitutive nitric oxide synthase(cNOS)in human osteoarthritis affected chondrocytes,and understand the function of cNOS in the pathogenesis of osteoarthritis(OA).Methods:The cartilage tissue from OA was used to detect cNOS expression by histology and in situ hybridization.Results:cNOS expression presented a high level in human osteoarthritis affected chondrocytes.Conclusion:The expression of cNOS in cartilage may play an important role in the pathogenesis of human OA.更多还原