【摘要】 采用葡聚糖蓝２０００为胃肠蠕动排空的内标记物，以自制的胃动合剂（散）及其分剂对小鼠胃排空和小肠推进功能的影响观察。胃动合剂（散）及分剂１、２、３、４为治疗组，胃肠促动力药普瑞博思（西沙比利）片剂为阳性对照组，阿托品片剂为阴性对照组。将实验用小鼠随机分组，分别灌服相应药物０．５ｍｌ／只。空白对照组灌服去离子水，１５分钟后灌服２％葡聚糖蓝溶液０．４ｍｌ／只，再过１５分钟后处死动物，取出胃，并以分光光度计测胃内色素的残留量及测量自幽门括约肌至小肠色素移动最前端的距离和幽门括约肌至盲肠根部的总距离，以两者的百分比为小肠推进比，并求出各组的均值，实验重复３次。结果显示：中药胃动合剂及其分剂均有明显促进胃排空和小肠推进功能，胃动合剂（散）和分剂４号作用强度与全胃肠道促动力药西沙比利相似，在促进小肠排空方面，分剂效果更优更多还原

【Abstract】 The effect of self made Weidong mist and its separate agents on gastric evacuation and enteric propulsion have been studied by using Blue Dxtran 2000 as the internal label Taking Weidong mist and its separate agents 1,2,3,4, as treatment groups,gastric motive drug prepulsid tablets as positive control.Atropine tablets as negative control.Lab mouse were random grouped.Then first filled the grouped mice with corresponding preparations 0 5ml per mouse filled the blank control group with non ion water;second,filled per mouse with 2% detran solution 0 4ml after 15 minutes;thrid,killed the mice and took out the stomach after another 15 minutes;finally measured the pigment residual in mice stomach by spectrophotoner,measured the distance from pylorus sphincter to the far front of enteric where the pigment moved to,the distances from phlorus sphincter to cecum radix,and calculated the average percentage between these two distances as the enteric prepulsive ratio;repeated the experiment three times.The result showed that both the Chinese medicine Weidong mist and its separate agents had obvious effect on promoting gastric evacuation and enteric propulsion.Weidong mist and separate agent 4 had similar effect to gastric motive drug prepulsid,separate agents 4 had better effect in promoting enteric evacuation.更多还原