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硫酸软骨素对软骨细胞琥珀酸脱氢酶活性的影响及意义
Effects of Chondroitin Sulfate on Activity of Succinate Dehydrogenase in Chondrocytes in vitro
【摘要】 目的探讨硫酸软骨素对软骨细胞增殖影响的作用机制及其在耳硬化症防治上的应用前景。方法用硝基四氮唑蓝法研究硫酸软骨素对体外培养兔软骨细胞琥珀酸脱氢酶(SDH)活性的影响。结果对照组与实验组SDH活性无明显差异,即加入或不加入硫酸软骨素的兔软骨培养细胞内SDH活性无明显改变(P>0.05)。结论硫酸软骨素有望用于治疗耳硬化症
【Abstract】 bjective To figure out the mechanism of chondroitin sulfate on the proliferation of chondrocytes and the possible role chondroitin sulfate may play in treating otosclerosis. Methods The effect of chondroitin sulfate on the succinate dihydrogenase(SDH) of chondrocytes were measured by nitroblue tetrazolium method. Results No difference was demonstrazed between the activity of SDH on control group and experiment group(P< 0.05 ).\ So the activity of SDH was unaffected by chondroitin sulfate. Conclusion Chondroitin sulfate may be used in treatment of otosclerosis.
【Key words】 chondrocyte; chondroitin sulfate; otosclerosis; succinate dehydrogenase;
- 【文献出处】 福建医科大学学报 ,JOURNAL OF FUJIAN MEDICAL UNIVERSITY , 编辑部邮箱 ,1998年02期
- 【分类号】R965
- 【被引频次】3
- 【下载频次】99