【摘要】 目的探讨胰岛细胞抗体（ＩＣＡ）与糖尿病分型、治疗及预后判断的关系。方法用间接免疫荧光法对３７例胰岛素依赖型糖尿病（ＩＤＤＭ）、３０例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）及其他自身免疫性疾病、正常人对照组各３０例进行ＩＣＡ测定。结果ＩＣＡ在ＩＤＤＭ中阳性率为４８．６％，明显高于对照组，并随病程延长ＩＣＡ阳性率下降显著（Ｐ＜０．０５）。ＩＣＡ在ＩＤＤＭ及ＮＩＤＤＭ中阳性率差异具有显著性（Ｐ＜０．０５）。结论ＩＣＡ对糖尿病分型、指导治疗及阐明发病机理具有一定意义。更多还原

【Abstract】 Objective\ To investigate the significance of islet cell antibodies(ICA) in the diagnosis,treatment and elucidation of mechanism of diabetes mellitus.\ Methods\ ICA were measured by immunofluorescence method in 30 healthy subjects,30 patients with autoimmune diseases,37 IDDM and 30 NIDDM patients.\ Results\ The incidence of ICA in IDDM patients was 48 6%(18/37) \ It was significantly higher than that in NIDDM patients(P<0 05) and significantly decreased with the course of diabetes There was sigificant difference in ICA between IDDM and NIDDM(P<0 05).\ Conclusion\ ICA will be of clinical value in the diagnosis、treatment and elucidation of mechanism of diabetes mellitus.更多还原