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血清胰岛细胞抗体测定的临床意义
The Significance of Islet Cell Antibodies Detection in Diabetes Mellitus
【摘要】 目的探讨胰岛细胞抗体(ICA)与糖尿病分型、治疗及预后判断的关系。方法用间接免疫荧光法对37例胰岛素依赖型糖尿病(IDDM)、30例非胰岛素依赖型糖尿病(NIDDM)及其他自身免疫性疾病、正常人对照组各30例进行ICA测定。结果ICA在IDDM中阳性率为48.6%,明显高于对照组,并随病程延长ICA阳性率下降显著(P<0.05)。ICA在IDDM及NIDDM中阳性率差异具有显著性(P<0.05)。结论ICA对糖尿病分型、指导治疗及阐明发病机理具有一定意义。
【Abstract】 Objective\ To investigate the significance of islet cell antibodies(ICA) in the diagnosis,treatment and elucidation of mechanism of diabetes mellitus.\ Methods\ ICA were measured by immunofluorescence method in 30 healthy subjects,30 patients with autoimmune diseases,37 IDDM and 30 NIDDM patients.\ Results\ The incidence of ICA in IDDM patients was 48 6%(18/37) \ It was significantly higher than that in NIDDM patients(P<0 05) and significantly decreased with the course of diabetes There was sigificant difference in ICA between IDDM and NIDDM(P<0 05).\ Conclusion\ ICA will be of clinical value in the diagnosis、treatment and elucidation of mechanism of diabetes mellitus.
- 【文献出处】 福建医科大学学报 ,JOURNAL OF FUJIAN MEDICAL UNIVERSITY , 编辑部邮箱 ,1998年01期
- 【分类号】R446.62,
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