【摘要】 目的　探讨肺癌细胞凋亡水平与肺癌发生、发展和预后的关系。方法　应用TUNEL法检测 12 4例人非小细胞肺癌组织、癌旁肺组织和 4 0例正常肺组织中细胞凋亡水平。结果　 ( 1)肺癌组织细胞凋亡指数 (AI)明显低于癌旁肺和正常肺组织 (P <0 .0 1) ;( 2 )肺癌细胞凋亡水平与肺癌P TNM分期、淋巴结转移状态有密切关系 (P <0 .0 5 ) ,而与肺癌组织学类型、细胞分化程度、原发肿瘤大小、部位、患者性别、年龄以及吸烟与否均无明显关系 (P >0 .0 5 ) ;( 3 )肺癌患者肺癌细胞凋亡高水平组 5年生存率( 4 5 .5 7% )明显高于凋亡低水平组 ( 14 .69% ) (P <0 .0 1)。结论　细胞凋亡水平异常可能在肺癌发生、发展和预后中起重要作用。检测肺癌细胞凋亡水平有助于判断肺癌患者预后和指导术后治疗。更多还原

【Abstract】 Objective To explore the relationship between the apoptotic level of lung cancer cell and oncogenesis, development and prognosis of lung cancer.Methods The apoptotic level of lung cancer cell was detected in 124 non small cell lung cancer samples, and their normal lung tissues adjacent to cancer and 40 normal pulmonary tissues as control by TUNEL.Results (1)The apoptotic index (AI) in the lung cancer tissues was significantly lower than that in the normal tissues adjacent to lung cancer and normal lung tissues (P<0.01);(2)The AI of lung cancer cell was closely related to P TNM stages, lymph node involvement of the cancer (P<0.05),but no close relation was observed among the AI, histological classification, cancer differentiation, size of the primary tumor, site of the cancer, age, sex of patients and smoking or not (P>0.05);(3)The 5 year survival rate (45.57%) of patients in high AI group was significantly higher than that (14.69%) in lower AI group (P<0.01).Conclusion Apoptotic suppression of lung cancer cells may play an important role in the oncogenesis, development and prognosis of lung cancer. Detection of apoptosis of lung cancer cells might be helpful to predict prognosis and guide the postoperative treatment in patients with lung cancer.更多还原