【摘要】 为探讨头颈部癌术前辅助治疗后肿瘤退缩区组织的DNA变化,应用流式细胞仪及常规病理方法,研究了30例口腔及咽喉部鳞癌术前辅助治疗后肿瘤组织及肿瘤退缩区组织的组织形态及DNA含量。结果表明,术前辅助化疗后肿瘤退缩区组织,虽然光镜下形态正常,但仍以DNA异倍体为主(28/30),增殖指数、G0/G1、G2/M的值,肿瘤退缩区与瘤体无明显差异,S期的比率较瘤体降低。因此,化疗后肿瘤退缩区在手术中若保留应持慎重态度。并对有关病例选择、标本取材等进行了讨论。更多还原

【Abstract】 To invest the changes of DNA content of head and neck cancer after preoperation adjuvent therapy, the flow cytometric analysis were used in 30 cases of patients who suffered from head and neck squamous cell carcinoma. The results indicated that there were no difference of DNA ploid, differencial index, G0/G1, G2/M between tumor tissue and tumor retreat region, although the tissue feature is normal in tumor retreat region. The S phrase rate is lower in retreat region than that of tumor tissue. We concluded that it should be cautious to ramain the retreat region while operation.更多还原