【摘要】 本实验通过给BALB/C小鼠腹腔接种柯萨奇B_-3m病毒(CVB_3m)诱发病毒性心肌炎（VMC）,感染病毒9d后,VMC检出率93.33％。应用原位末端标记法（T/VNEL）及免疫组化技术检测发现:76.67％感染病毒鼠心肌中发现凋亡细胞,73.33％有TGF—β₁的表达,二者之间分布区域一致。提示细胞凋亡可能参与CVB_3m诱导的VMC的发生、发展,而TGF—β₁可能参与VMC细胞凋亡的调控。更多还原

【Abstract】 In the experiment Viral myocarditis (VMC) in BALB/c mouse was obtained by Coxsackie virus-B3m (CVB3m) that was inoculated into abdominal cavity. The rate of VMC was 93. 33% after 9 days of virus infection. The apoptosis(76. 67%) and expression of TGF -B1(73. 33%)found in the cell smear of myocardium of infected mouse by TdT/dvTp Nick End Labelling and immunohistochemical method. The rusults showed apoptosis may participate in occurrence and development of VMC ,and that TGF - B1 may participated in abjustment of apoptosis of VMC.更多还原