【摘要】 从家蚕（Ｂｏｍｂｙｘｍｏｒｉ）免疫蛹血淋巴中提取抗菌肽，以Ｓ１８０荷瘤小鼠和艾氏腹水瘤荷瘤小鼠为模型，研究抗菌肽的抗癌效应。结果表明，抗菌肽明显抑制Ｓ１８０瘤重，３７９２、４５４２和４９８０Ｕ３种剂量抑瘤作用分别为４２．８６％、３９．１３％和３７．８９％。抗菌肽对外周血白细胞数没有影响。病理切片显示，注射抗菌肽荷瘤小鼠癌瘤组织大面积坏死，癌瘤周围组织内有大量炎细胞（单核细胞、中性粒细胞和淋巴细胞）浸润。抗菌肽亦可使艾氏腹水瘤（ＥＡＣ）腹水生成量减少。更多还原

【Abstract】 Taking S180-bearing mice and EAC-bearing mice as animal models,the antibacterial peptide (ABP) purified from the haemolymph of the silkworm (Bombyx mori) pupae was used to investigate the effects against the turmor in vivo. The results showed the ABP significantly inhibited turmor weight. The inhibitory rate of ABP at dose of 3792,4542,4980 U·(0.5 mL·20 g·d) -1 ×10 d,i.p. were 42.86%,39.13% and 37.89% respectively. ABP had no inhibitory effects on the number of leukocytes. Histopathological assay showed that ABP induced tumor tissue necrosis in large scales and there were lots of inflammatory cells (monocytes,neutrophils and lymphocytes) around tumor cells. It also could obviously reduce EAC peritoneal ascites fluid.更多还原