【摘要】 本研究选用１月龄小鼠，观察了海马内注射ＣａＣｌ２造成高钙水平对小鼠学习和记忆行为的影响，并对海马ＣＡ３区进行突触超微结构定量分析。结果表明，与对照组相比：（１）ＣａＣｌ２组小鼠一次性被动回避反应的步入潜伏期有缩短的趋势，说明该组小鼠记忆减弱；同时Ｙ－迷宫分辨学习能力也显著下降（Ｐ＜０．０１）；（２）ＣａＣｌ２组海马ＣＡ３区突触后致密物质极显著变薄（Ｐ＜０．００１），而突触间隙宽度显著增大（Ｐ＜０．０５）。结果提示，海马突触界面结构参数的变化可能是Ｃａ２＋浓度过高损害学习记忆功能的形态结构基础。更多还原

【Abstract】 お? In this study,the effect of high Ca2+ level by injecting CaCl2 into bilateral hippo-campus on the learning and memory behavior of young mice was investigated,and the synaptic structural parameters in the hippocampal CA3 area were quantitatively analysed.The main results were as follow,compared with control:(1) The STL(step-through latency)of CaCl2 group was shortened in one trial passive avoidance response,and the descrimination learning capacity of CaCl2 group in Y-maze was greatly attenuated(P<0.01),showing the severe impairment of learning and memory in this group. (2) The thickness of post-synaptic density(PSD)of CaCl2 group was thinned signi-ficantly(P<0.001),while the width of synaptic cleft of this group was apparently increased(P<0.05). These results suggested that the learning and memory dysfunction caused by over-loaded calcium ions in hippocampus might based on the morphological changes of the synaptic interface stucture.更多还原