【摘要】 利用免疫组织化学方法检测了２０例良性病变及３７例恶性病变中错配修复基因ＭＬＨ１及ＭＳＨ２基因产物的表达。结果发现：ＭＬＨ１在良性病变中表达的阳性率为７０％（１４／２０），在恶性病变中为４８６％（１８／３７）；ＭＳＨ２在良性病变中表达的阳性率为２０％（４／２０），在恶性病变中为３７８％（１４／３７）。结果说明不同的ＤＮＡ错配修复基因产物在良恶性病变中表达存在差异。更多还原

【Abstract】 Both of MHL1 and MSH2 belong to mismatch repair (MMR) gene family.The gene expressions of MHL1 and MSH2 in 20 cases of benign and 37 cases of malignant tumors were examined immunohistologically with ABC method.The positive expressions of MHL1 were found in 14 out of 20 benign lesions and 18 out of 37 malignant lesions,however,those of MSH2 were found in 4 out of 20 benign lesions and 14 out of 37 malignant.The relationship between MMR gene product expression and malignany of tumor will be farther researched.更多还原