【摘要】 目的：观察慢性肾炎（ＣＧＮ）时血小板α－颗粒膜蛋白（ＧＭＰ１４０）活性的改变及其与肾小球滤过率（ＧＦＲ）的关系。方法：采用抗人活化血小板α－颗粒膜蛋白１２５Ｉ标记的单克隆抗体，以单位点放射免疫法直接定量测定４３例ＣＧＮ患者和２０例正常人血小板ＧＭＰ１４０，并用９９ｍＴｃＤＴＰＡ检测ＧＦＲ。结果：发现ＣＧＮ患者ＧＭＰ１４０分子数显著高于正常对照组，随ＧＦＲ下降ＧＭＰ１４０也逐渐下降，二者呈正相关。结论：ＧＭＰ１４０测定有助于肾小球疾病发病机理及进行性肾脏损害的研究，对于抗血小板药物的选用具有指导意义更多还原

【Abstract】 Objective: To observe the changes of platelet alphagranule membrane protein（GMP140） in patients with chronic glomerulonephritis（CGN） and to reveal their relation with glomerular filtration rate （GFR）. Methods: Using125I antihuman activated platelet GMP140 monoclonal antibody, the quantitative measurement of platelet GMP140 in 43 patients with CGN and 20 healthy individuals, by direct unit radioimmunoassay, and GFR by^99m TcDTPA were performed. Results:The number of molecule platelet GMP140 of patients with CGN [（1 745±113）M] was significantly higher than that of normal subjects [（912±51）M], P<0.01; in CGN,the GMP140 gradually declined with the decrease of GFR,and it was positively correlated with GFR （r=0.386,P<0.05）. Conclusion: The GMP140 can be used to study the pathogenesis of glomerular diseases and progressive renal injury, and to select antiplatelet agents.更多还原