【摘要】 利用雄性ＳＤ大鼠每日经口给予有机锗（Ｇｅ－１３２）１００、２５０、５００ｍｇ／ｋｇ连续二十五ｄ，发现高剂量组的肝细胞色素Ｐ４５０受到明显抑制（Ｐ＜０．０５）。对Ｐ４４８的标志酶乙氧基异吩口恶唑脱乙氧基酶（ＥＲＯＤ）的抑制也近５０％；动物以Ｇｅ－１３２５００ｍｇ／ｋｇ／ｄ预先处理２０ｄ，再分别给予苯巴比妥钠盐（ＰＢ）、３－甲基胆蒽（３－ＭＣ），发现Ｇｅ－１３２对ＰＢ诱导Ｐ４５０的抑制不明显，而对３－ＭＣ诱导ＥＲＯＤ的抑制仍达３３％。更多还原

【Abstract】 Male SD rats were fed orally with Ge-132 100, 250 and 500mg/kg each day for 25 days, Cyt P 450 of liver cell of high dose group was inhibited significantly (P<0.05), EROD activity was also inhibited about 50 percent in the group compared with the control. The animals were pretreated with Ge-132 500mg/kg/d for 20 days, then give PB and 3-MC, found that the inhibition of P 450 induced by PB was not obvious, but there was 33 percent inhibition of EROD activity induced by 3-MC.更多还原