【摘要】 对３０例顽固性癫痫病人进行拉莫三嗪开放添加治疗。为期三个月。以后仍服用，剂量１００～４００ｍｇ／ｄ，（平均２２６．５±９２．４）。３０例患者总的癫痫发作次数减少４６％，１３％完全控制。拉莫三嗪对控制各类癫痫发作均有效，总显效率达６７％，不良反应较少，主要是变态反应性皮疹，停药后消失，实验室检查完全正常更多还原

【Abstract】 Thirty refractory epileptic patients who entered on a open add on trial. The treatment period was 3 to 17 months. These patients were taking a daily Lamotrigine (LTG) dosage of 100 400 mg(mean 225.6±92.44). The percentage of reduction of seizure frequency as compared with the pre LTG period(3 mouths of baseline) was 62%, seizure free 13%. LTG appeared to be effective over a broad range of different seizure types . The most importment adverse event reported by our patients was allergic skin rashes, which were generally mild and disappeared when the treatment was discontinued. Laboratory parameters showed normal.更多还原