【摘要】 利用生物检定法,观察黄芪对猪冠状动脉(简称冠脉)螺旋肌条的作用。研究表明:黄芪注射液可以拮抗氯化钾和组胺所致冠脉的收缩。表现为先给予不同浓度黄芪后,两者的致收缩曲线明显压低,并呈量效关系。在氯化钾和组胺引起冠脉条收缩达最大效应时,黄芪可阻断它们的收缩。结果提示:黄芪有直接扩张冠脉效应,临床可用来治疗冠脉痉挛引起的疾病,用于预防效果更佳。更多还原

【Abstract】 Bioassay was used to study the effects of Radix Astragali (RA) on spiral strips of porcine coronary artery.It showed that RA inhibited contraction of strips induced by KCI and histamine.RA (20～80 mg/ml) was added into medium 30 s prior to KCI and histamine respectively,and the contraction curve of them decreased significantly in dose-dependent manner.RA also blocked contraction of strips induced by KCI and histamine.The results indicated that RA might dilate coronary artery directly, and it is thought to be effective in angina caused by coronary artery spasm,especially useful in prevention.更多还原