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恒河猴肾囊注射川芎嗪对肾小球滤过率的影响

Effect of Tetramethyipyrazine on Glomerular Filtration Rate by Renal intracapsular Injection in Rhesuses

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【作者】 王玉柱; 蔡美顺; 于仲元; 何红; 王洋; 高伯山;

【Author】 Wang Yu-zhu Cai Mei-shun Yu Zhong-yuan Renal Division,People’s Hospital,Beijing Medical University,Beijing(100044)

【机构】 北京医科大学人民医院; 北京医科大学人民医院 (北京100044); (北京100044);

【摘要】 哺乳动物的肾脏被较厚的脂肪囊包被。定期在8只健康恒河猴肾囊内注射中药川芎嗪注射液,注射前后分别用核素99mTc-DTPA 测定肾小球滤过率。结果显示,肾囊注射后肾小球滤过率较注射前有显著增加(P<0.05),为肾囊注射给药治疗多种肾脏疾病提供了实验依据,同时进一步显示了中药川芎嗪对肾功能的改善作用。

【Abstract】 The kidneys of mammal are encapsulated with adipose capsule.Tetramethylpyrazine was injected into the adipose capsule of 8 rhesuses periodically.The glomerular filtration rate(GFR)was determined with nuclide 99mTc-DTPA before and after intracap- sular injections.The results showed that the GFR was increased obviously after intracapsular injections(P<0.05).This study provided experimental support for renal intracapsular injective therapy and also demonstrated the protective effect of Tetram- ethylpyrazine on renal function.

  • 【文献出处】 中国中西医结合杂志 ,Chinese Journal of Integrated Traditional and Western Medicine , 编辑部邮箱 ,1997年S1期
  • 【分类号】R285.5
  • 【被引频次】4
  • 【下载频次】49
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