【摘要】 采用敏感的白细胞介素６（ＩＬ６）依赖细胞株ＫＤ８３增殖实验检测６０例急性白血病（ＡＬ）患者血清ＩＬ６活性，同时用ＥＬＩＳＡ法测定相应患者血清肿瘤坏死因子（ＴＮＦ）水平，发现ＡＬ患者血清ＩＬ６和ＴＮＦ水平明显高于正常对照（Ｐ＜０．０１），并与白血病的分型有关。动态观察４６例ＡＬ患者，发现疗效不同ＩＬ６和ＴＮＦ的水平及变化情况也不同。本研究提示，ＩＬ６和ＴＮＦ可能参与了ＡＬ的发病过程，测定ＡＬ患者血清ＩＬ６和ＴＮＦ水平可能对病情监测和疗效判断有一定的参考价值。更多还原

【Abstract】 Serum IL 6 activities were determined in 60 patients with acute leukemia(AL) by the sensitive IL 6 dependent cell lines KD 83 proliferation experiment, and the ELISA method was used to measure serum TNF level. The results demonstrated that serum IL 6 activity and TNF levels in AL patients were significantly higher than those in control group, and were correlated with the type of acutl myelemia. Through the follow up observation of 46 previously untreated AL patients, it was found that different serum IL 6 and TNF levels and changes happened in patients with different effectiveness of treatment. These results suggested that serum IL 6 activities and TNF levels may have some clinical significance in monitoring the progress of disease and evaluating the effectiveness of therapy for patients with AL.更多还原