【摘要】 为研究褪黑素的改善睡眠作用，通过直接睡眠试验、与戊巴比妥钠协同睡眠试验，观察褪黑素诱导小鼠的睡眠作用。结果显示：褪黑素８００ｍｇ／ｋｇＢＷ剂量灌胃小鼠，有直接诱导小鼠睡眠作用（Ｐ＜０．０１），睡眠时间为７０．８ｍｉｎ，潜伏期为３５．７ｍｉｎ；０．０８３、０．５、３．０ｍｇ／ｋｇＢＷ剂量，能显著延长戊巴比妥钠诱导的小鼠睡眠时间（Ｐ＜０．０１），显著增加戊巴比妥钠阈下剂量诱导的小鼠睡眠发生率（Ｐ＜０．０５、Ｐ＜０．０１）。由此可见，褪黑素具有改善小鼠睡眠作用更多还原

【Abstract】 Examination of sleep-inducing effect of Melatonin, through direct sleep-inducing test and the test of sleep-inducing in coordination with pentobarbitone in mice revealed that, oral low doses of Melatonin (0.083,0.5,3.0mg/kg BW) potentiated pentobarbitone-inducing sleep, and that higher dose (800mg/kg BW) had direct sleep-inducing effect, the sleep time is 70.8 minutes, sleep latency is 35.7 minutes. Author’s address Zhou Yuhong, Institute of Food Safety Control and Inspection, the Ministry of Public Health of PRC, Beijing 100021, PRC.更多还原