【摘要】 目的　研究巨大型侵袭性垂体腺瘤的临床特点及治疗方法。　　方法　回顾性分析 67例巨大型侵袭性垂体腺瘤 ,并与 2 2例非侵袭性垂体腺瘤比较。　　结果　巨大型侵袭性垂体腺瘤临床表现以内分泌紊乱多见 ,头痛、视力视野损害的发生率明显高于对照组 ,并较对照组更多出现侵犯颅外和周围脑组织引起的各种症状。CT值为 52 2Hu ;MRT1 加权呈等信号或混杂信号 ,T2 加权高信号多见 ,混杂信号次之。本组全切除加次全切除率为 61 2 % ,以扩大额下硬膜外入路及经额入路的效果较好。术后并发症和肿瘤复发率高于对照组 ,生活质量低于对照组。　　结论　巨大型侵袭性垂体腺瘤临床表现复杂 ,影像学检查信号特殊 ;提高肿瘤的全切除率及术后常规放疗是提高疗效的重要措施。更多还原

【Abstract】 Objective To explore the clinical features and treatment of giant invasive pitui~tary adenomas. Methods Retrospectively analysed 67 cases of giant invasive pitui~tary adenomas, comparing with 22 cases of non-invasive pituitary adenomas. Results The giant invasive pitui~tary adenomas had complex clinical features, including endocrinal disorders, severe headache, deficit of eyesights, as well as the features caused by the invasion of extracranial and surrounding tissues. The mean CT value was 52 2 Hu, the MR T 1 power signal was iso-signal intensity or mixed signal intensity, T 2 power showed high signal intensity or mixed signal intensity. The total or subtotal remove rate were 61.2%, and the expanded sub-trontal extra-dural approach or trans-frontal approach were advantage. There were more complications and reoccurence with the giant tumors. Conclusions The giant invasive pituitary adenomas had complex clinical features and special images. It was important management that remove tumor as possible as and undergo a routine radiotherapy postoperatively.更多还原