【摘要】 放免法测定92例糖尿病人和30例正常人的血浆血栓素B2（TXB2）和6—酮—前列环素F1α（6－keto－PGF1α）浓度．结果显示，TXB2随DN加重逐渐升高（P＜0．05或更低），DN越重，TXB2升高越明显；TXB2／6－keto－PGF1α比值变化与TXB2水平一致；尿白蛋白排泄率正常组和早期DN组病人尿白蛋白排泄率与TXB2直线正相关（r＝0．24，P＜0．05）．提示血栓素升高在DN的发病机制和进程中有作用。更多还原

【Abstract】 We measured the plasma thromoxane B, and 6 -keto-prostaglandin F1α using radioimmunoassay in 92 diabetic patients and 30 normal subjects. The results showed that the TXB2 and TXB2/6- ketoPGF1α ratio were significantly higher in DM,IDN,DNA groups than those in the normal subjects (p<0. 05 or lower) ;the TXB2 level was significantlycorrelated with urinary albumin excretion rate in DM and IDN groups (r=0. 241, p<0.05). The results suggest that thromboxane involve in the pathogenesis of diabetic nephropathy and play a rolin the progression.更多还原