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非发酵菌属对17种临床常用抗生素的耐药特性

CHARACTERISTICS OF RESISTANCE TO SEVENTEEN ANTIMICROBIAL AGENTS AMONG NONFERMENTER ISOLATES

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【作者】 朱三明; 张嵘; 宣贵达;

【Author】 Zhu Shanming; Zhang Rong (Second Affiliated Hospital, Zhejiang Medical University)Xuan Guida (Department of Medical Chemistry, Zhejiang Medical University)

【机构】 永康市人民医院检验科; 浙江医科大学附属第二医院检验科; 浙江医科大学医用化学教研室;

【摘要】 为了探讨细菌耐药性不断增长的问题,我科检测了1994年6月到1996年6月从医院内感染临床分离得的1362株非发酵菌对17种临床常用抗生素的敏感性。用K-B纸片法和Vitek-Ams药敏卡,根据抑菌环直径,用检验科软件分析其耐药率。发现除第三代头孢菌素、氟喹喏酮类、亚胺培南及多粘菌素B抑菌效果较好外,其余耐药率均很高。由于头孢菌素联合舒巴坦,有很好的抗菌效应,建议临床扩大使用β-内酰胺类抗生素与舒巴坦联合的制剂。本文结果为临床选用抗生素提供参考。

【Abstract】 A total of 1362 nonfermenter strains was isolated from pathological samples (such as sputum, urine, wounds, blood and others) and collected during a period from June 1994 to June1996. Isolates were identified as nonfermenters based upon Disk diffusion and Vitek-Ams systemtest. The resistance rates of ceftazidime, ciprofloxacin, norftoxacin, imipenem, cefoperazone/sulbactam and polymyxin B against strains of nonfermenters were accepted. The resistance ratesof others were high (over 40% ). The results are helpful in selecting antibiotics for clinical use.

【关键词】 非发酵菌属; 细菌; 抗生素类; 药物耐受性;
【Key words】 Bacteria; Nonfermenters; Antibiotic; Drug tolerance;
  • 【分类号】R446.5
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