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氩激光虹膜切除术后房水内SOD和PGE2变化与眼压的关系

The relation of the changes of SOD and PGE2 in aqueous humor with the transient rise of intraocular pressure after argon laser iridectomy

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【作者】 何剑峰仇宜解孙为荣牛膺筠张立贵孟瑞华孟旭霞

【Author】 He Jianfeng, Qiu Yijie, Sun Weirong, et al. Department of Ophthalmology, The Affiliated Hospital of Qingdao Medical College, Qingdao 266003

【机构】 青岛医学院附属医院眼科

【摘要】 目的探讨氩激光虹膜切除术后暂时性眼压升高的发生机制。方法观察家兔氩激光虹膜切除术后15分钟、60分钟、6小时、24小时和48小时眼压及房水内前列腺素E2(prostaglandinE2,PGE2)浓度和超氧化物歧化酶(superoxidedismutase,SOD)活性的变化及术前应用消炎痛、可的松、维生素E、维生素C等药物对术后暂时性眼压升高的影响。结果激光术后暂时性眼压升高均发生在术后6小时内,眼压升高的同时伴有房水内PGE2浓度增加和SOD活性显著下降。术前各用药组术后暂时性眼压升高的幅度明显降低。眼部各滴药组术后房水内PGE2浓度无明显增加,肌注组术后房水内SOD活性无显著下降。结论氩激光虹膜切除术后暂时性眼压升高与术后房水内PGE2浓度增加和SOD活性下降有关,术前应用消炎痛、可的松及维生素E、维生素C等药物对术后暂时性眼压升高有防治作用。

【Abstract】 Objective To study the mechanism of transient rise of the intraocular pressure (IOP) after argon laser iridectomy (ALI). Methods The rabbit changes of IOP, the activity of superoxide dismutase (SOD) and the concentration of prostaglandin E2 (PGE2) in aqueous 15 min, 60 min, 6hr, 24hr, 48hr after ALI, the relationships of these changes with the transient rise of IOP, and the effects of using indomethacin, cortisone, vitamin E and C before ALI on the transient rise of IOP were observed. Results After ALI, the transient rise of IOP took place within postoperative 6 hr. Following the postoperative transient rise of IOP, the concentration of PGE2 in the aqueous was markedly increased, but the activity of SOD in the aqueous markedly decreased. When indomethacin, cortisone, vitamin E and C were used before ALI, the concentration of PGE2 was not markedly increased, the activity of SOD was not markedly decreased and the postoperative transient rise of IOP did not take place. Conclusions The transient rise of IOP after ALI is related to the increase of concentration of PGE2 and the decrease of activity of SOD in the aqueous. Using indomethacin, cortisone, vitamin E and C before ALI can effectively prevent the postoperative transient rise of IOP.

  • 【文献出处】 中华眼科杂志 ,CHINESE JOURNAL OF OPHTHALMOLOGY , 编辑部邮箱 ,1997年06期
  • 【分类号】R779.63
  • 【被引频次】6
  • 【下载频次】36
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