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幽门螺杆菌感染患者白细胞介素-8和肿瘤坏死因子-α的表达

DETECTION OF INTERLEUKIN 8 AND TUMOR NECROSIS FACTORα IN HELICOBACTER PYLORI INFESTATION CASES

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【作者】 余柏林刘重贞荣珍李艳周有利杨道华

【Author】 Yu Bolin,Liu Chongzhen,Rong Zhen,et al.Yunyang Medical College,Shiyan Hubei 442000

【机构】 郧阳医学院微生物学教研室

【摘要】 为研究幽门螺杆菌(Hp)感染时血清及胃粘膜组织白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α水平及其病理作用,采用放射免疫法和酶联免疫吸附试验夹心法分别检测了Hp(-)~(+++)者血清和胃粘膜组织中的IL-8、TNF-α,并观察胃粘膜组织炎症活动程度与Hp感染密度的关系。结果:(1)胃粘膜组织IL-8、TNF-α水平高低依次为Hp感染(+++)>(++)>(+)>对照组,4组间差异均有显著意义(P<0.05)。(2)Hp根除后血清IL-8水平无明显变化,TNF-α水平则明显下降;胃粘膜组织IL-8、TNF-α水平下降,与根除前相比有显著性差异(P<0.05)。(3)胃粘膜组织炎症活动程度与Hp感染密度相关(精确概率值为0.0026,P<0.01)。结果提示:Hp感染时胃粘膜组织IL-8、TNF-α水平明显高于对照组,损伤程度随Hp感染密度增加而加重

【Abstract】 Here reports the results of a research on relations between Helicobacter pylori(Hp) infestation and IL8 and TNFα activity and their pathological mechanism in serum and gastric mucosa as well as its inflammatory activity.The detective methodology was radioimmunity and ELISA sandwich.The findings turned out as follows:(1)IL8 activity:in serum Hp infestation(+),(++),(+++)showed no distinct variation (P>005) compared with the control;in gastric mucosa gave an evident increase with distinct difference (P<005)between groups and against the control;in gastric mucosa revealed an evident change (P<005) before and after extirpation.(2)TNFα activity:in serum and gastric mucosa exhibited an obvious variation between Hp infestation(+++),(++),(+)and control group with significant change(P<005)before and after eradication.(3)Gastric mucosa inflammatory activity was in a relevance with Hp infestation .It is concluded that IL8 and TNFα activity increased dramatically in gastric mucosa in Hp infestation ,that the severity of gastric mucosal injury was  relevant with Hp infectional density.As a neutrophilic chemotactic factor,IL8 plays a significant role in mucosal injury .The measurement of serum TNFα activity was of some value for diagnosis and curative effect of gastric mucosal injury due to serious Hp infestation.

  • 【文献出处】 中华消化内镜杂志 ,CHINESE JOURNAL OF DIGESTIVE ENDOSCOPY , 编辑部邮箱 ,1997年06期
  • 【分类号】R573.1
  • 【被引频次】9
  • 【下载频次】28
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