【摘要】 为探讨乳腺癌血管生成与淋巴结转移的关系，作者采用免疫组织化学方法检测了１９８４年至１９８５年手术切除的７０例原发性乳腺癌石蜡标本组织中的微血管密度（ＭＶＤ）及血管内皮生长因子（ＶＥＧＦ）表达，其中有腋淋巴结转移（ＬＮ＋）者３１例，无腋淋巴结转移（ＬＮ－）者３９例。光镜下，２００倍视野计数ＭＶＤ，４００倍视野计数ＶＥＧＦ阳性细胞。结果显示：ＬＮ＋组的ＭＶＤ及ＶＥＧＦ表达显著高于ＬＮ－组；ＭＶＤ及ＶＥＧＦ等级在ＬＮ＋组亦高于ＬＮ－组。作者认为：原发性乳腺癌组织中的ＭＶＤ及ＶＥＧＦ表达与肿瘤的转移行为密切相关，有可能作为判定肿瘤生物学行为、转移潜能及预后的指标。更多还原

【Abstract】 To study the relationship between tumor angiogenesis and lymph node metastasis in primary breast carcinoma.Agiogenesis was assessed by the microvessel density(MVD) and expression of vascular endothelial growth factor (VEGF) using immunohistochemical staining.Paraffin embedded specimens from 70 patients with primary breast cancer who had undergone radical mastectomy from 1984 to 1985 were studied.Thirty one patients had histologically proven positive axillary lymph node(N+).The axillary node negative(N-)group was composed of thirty nine patients.Microvessels per 200×(as MVD) and VEGF positively stained cancer cells per 400×were counted with light microscope. MVD and VEGF expression were higher in tumors with N+ showed than those with N-, MVD and VEGF expression were higher in N+ than in N-.MVD and the expression of VEGF are highly correlated with metastasis in primary breast cancer,which may serve as a parameter for determining tumor biological,metastatic potential and prognosis.更多还原