【摘要】 目的 探讨内皮素在肾性高血压及肾脏病发展中所起的作用。方法 检测了正常人、慢性肾小球肾炎患者血浆内皮素（PET-1）和24小时尿内皮素排泄量（UET-1）,内生肌酐清除率（Ccr）和尿β₂微球蛋白（β₂-m）。结果 所有患者PET-1和UEP-1水平均升高;且PET-1或UET-1与平均动脉压（MAP）和β₂-m呈正相关,与Ccr呈负相关。结论 内皮素参与肾性高血压形成和肾脏病进展,且UET-1是肾小管功能损害的一个指标。更多还原

【Abstract】 Objective To elucidate the effects on renal hypertension and progressive renal disease of endothelin-1 in patients of chronic glomerulonephritis. Methods Plasma endothelin-1 (PET-1 )N urinary excretion rate of endothelin-1 (UET-1 )., creatinine clearance (Ccr) and urinary excretion rate of 2-microglobulin (β2-m) in 27 patients with chronic glomerulonephritis and in 10 normal control were measured. Results The level of PET-1 and UET-1 in all patients was markedly elevated. Positive correlation between PET-1 or UET-1 and mean artery pressure (MAP) or β2-m, negative correlation between PET-1 or UTE-1 and Ccr were found. Conclusion Endothelin plays an important role in developing renal hypertension and in progressive renal diseases, and also UET-1 is a sensitive marker of renal tubular damage.更多还原