【摘要】 用光学放射自显影术对四氯化碳诱导的大鼠肝硬变模型肝组织α₁-受体进行研究,结果发现:正常肝组织结构间α₁-受体密度具有显著性差异（P<0.01）;肝硬变各期肝组织结构α₁-受体密度均显著低于正常组的相应组织结构（P<0.01）。本实验组肝内各组织结构α₁-受体的下降可能是四氯化碳的毒性作用和受体下行调节机制等多种原因共同作用的结果。更多还原

【Abstract】 By using the light autoradiography, the α₁-adrenoceptors in Wistar rats were investigated during the processes of CCl₄-induced cirrhosis with portal hypertension, The α₁-adrenoceptors anr extensively distributed in hepatic tissues of normal rats, and its density varied significantly from one individual structure to another（P<0.01）, in an order from high to low; hepatocytes>intrahepatic artery wells>intrahepatic portal walls>intrahepatic venous walls. The density of α₁-adrenoceptors in hepatic tissues in cirrhosis was remarkably lower than that of in normal rats （P<0.01） and the distibution of α₁-adrenoceptors showed no significant difference among different hepatic vascular walls of cirrhosis. The decrease of α₁-adrenoceptors in cirrhotic liver tissues may be caused by the toxic effects of CCl₄ and the downregulation of α₁-adrenoceptors.更多还原