【摘要】 为了探讨异种移植排斥反应与细胞因子的关系,检测猪-人混合淋巴细胞培养(MLC)中人类淋巴细胞的增殖反应及细胞因子含量,并与人类同种异体MLC进行比较。结果显示,前者增殖反应相当于或超过后者。两种MLC上清液中白细胞介素2和γ-干扰素的动态变化接近,且前者白细胞介素4的高峰值超过后者(P<0.05)。提示细胞因子在猪-人MLC中可能起着一定的作用。更多还原

【Abstract】 In order to explore the relationship between xenograft rejection and cytokines, the proliferative responses and cytokine contents from human lymphocyte were detected in porcine-human mixed lymphocyte culture (MLC) and compared with human allo-MLC. The results showed that the proliferative responses in the former was equal to or stronger than that in the latter, and the kinetics of IL-2 and IFN-γ in both supernatants were similar but the peak of IL-4 from the former was higher than that from the latter (P<0.05). This suggests that cytokines are likely to play roles in porcine-human MLC.更多还原