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人工气管腔内气管粘膜上皮再生的实验研究

Experimental studies on regeneration of epithelium mucosae of trachea in artificial trachea cavity

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【作者】 董驹隋铁泉张书申陈国生王天日王国臣张宇郭阳李占清孙大伟尹红玲佟树文张素华郑素勤曹世义

【Author】 Dong Ju; Sui Tiequan; Zhang Shushen; et al.(Dapartment of Thoracic Surgery, Affiliated Hospital, North China Coal Medical College, Tangshan 063000)

【机构】 华北煤炭医学院附属医院胸外科!唐山063000华北煤炭医学院?

【摘要】 为了研究气管粘膜上皮在人工气管腔内再生的难题,我们将12又成年犬分为3组,每组4只,A组采用自作带血管蒂大网膜包统在网孔型硅橡胶人工气管外壁行Ⅰ期气管置换术;B、C两组采用胎犬气管包绕在部分同孔型炭素纤维人工气管外壁,其外再包绕自体带血管帮大网膜,制成所谓人工气管—胎犬气管—大网膜复合体分别施行Ⅰ期吻合、Ⅱ期吻合的气管置换实验,结果A、B组没有观察到人工气管腔内气管粘膜的再生,C组可观察到人工气管腔内气管粘膜的再生,且动物存活时间长,生存质量佳。

【Abstract】 In order to study the regeneration of epithelium mucosae of trachea in artificial cavity of trachea and survival quality of experimental dogs, 12 adult dogs were divided into three groups. Group A(4 dogs) was transplanted with the artificial trachea made of silicon tube covered with vascular greater omentum’ Groups B and C (4 dogs in each) were transplanted with the artificial trachea which was encysted by embryonic trachea with vascular grcater omentum. Among them, 4 dogs (Group B)underwent primary suture, and the others (Groups C) secondary suture.The results showed that the severe inflammation and no regeneration of the tracheal mucosae was confirmed in groups A and B, and that the better regeneration of the tracheal mucosae and the bet ter survival quality and the longer survival time were observed in Group C.

【基金】 煤炭工业部出国留学人员科研基金
  • 【文献出处】 中华器官移植杂志 ,CHINEAE JOURNAL OF ORGAN TRANSPLANTATION , 编辑部邮箱 ,1997年02期
  • 【分类号】R318.1
  • 【被引频次】8
  • 【下载频次】48
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