【摘要】 司氟沙星由２，３，４，５－四氟苯甲酸经硝化、酰氯化、缩合、环合、还原、水解、酰化，再与顺式２，６－二甲基哌嗪缩合、水解而得，工艺简便，反应条件温和，可用于工业化生产。更多还原

【Abstract】 A facile preparation of sparfloxacin,starting from 2,3,4,5 tetrafluorobenzoic acid,via nitration,chlorination,condensation,cyclization,reduction,hydrolysis,acylation,piperazination,hydrolysis,etc,is described.The reactions of all steps were carried out in moderate conditions to be applicable to large scale preparation.更多还原