【摘要】 目的:观察利多卡因能否改善逆行脑灌注的脑保护作用。方法:16只杂种犬接受体外循环并降温至20C,停循环,逆行脑灌注120分钟,恢复体外循环并复温至36℃。利多卡因组（n=8）实验期间持续给予利多卡因(4mg·kg^-1后0.2mg·kg^-1·min^-1,逆行脑灌注期间为0.5mg·min^-1);对照组（n=8）则给予等量生理盐水。结果:实验末利多卡因组脑组织磷酸肌酸、三磷酸腺苷含量和能量指数均明显高于对照组（分别为磷酸肌酸:2.44±0.53比1.61±0.49μmol/gwetw,P<0.01;三磷酸腺苷:0.71±0.18比0.50±0.17μmol/gwetw,P<0.05;能量指数:0.59±0.10比0.48±0.09,P<0.05）。但两组间脑组织丙二醛含量无显著差异。结论:围逆行脑灌注期间持续给予利多卡因改善脑保护作用,可能与恢复体外循环后犬脑组织高能磷酸盐含量增加有关。更多还原

【Abstract】 Objective:To observe the effect of lidocaine on cerebral protection provided by retrograde cerebral perfusion. Method:Sixteen mongrel dogs underwent cardiopulmonary bypass and were cooled to 20 C. Circulation was then stopped and retrograde cerebral perfusion was carried out for 120 min,then CPB was resumed and animals were rewarmed to 36 C. Animals were divided into two groups:in lidocaine group（n=8）,lidocaine was administrated continuously throughout the experiment (4mg/kg then 0.2mg·kg^-1·min^-1 during cardiopulmonary bypass, 0.5mg/min during retrograde cerebral perfusion);in control group（n=8）,normal saline was given at the same rate. Result:Cerebral tissue creatine phosphate and adenosine triphosphate concentrations and energy charge were significantly higher in the lidocaine group than those in the control group by the end of the experiment （creatine phosphate:2.44±0.53 versus 1.61±0.49μmol/g wet w,P<0.01; adenosine triphosphate:0.71±0.18 versus 0.50±0.17μmol/g wet w,P<0.05; energy charge:0.59±0.10 versus 0.48±0.09, P<0.05）. There was no significant difference in the cerebral tissue malondialdehyde concentration between the two groups. Conclusion:Continuous lidocaine administration can improve the cerebral protective effect of retrograde cerebral perfusion, possibly through increasing the cerebral tissue high energy phosphate contents after resuming cardiopulmonary bypass.更多还原