【摘要】 目的:了解静脉点滴普鲁卡因对大脑皮质的影响。方法:对10例ASA Ⅰ～Ⅱ级、年龄29～59岁、拟行择期外科手术的病人,观察单纯静脉点滴4mg·kg^-1·h^-1异丙酚15分钟、异丙酚加1mg·kg^-1·min^-1与普鲁卡因复合麻醉30分钟以及再次单纯静滴异丙酚麻醉15分钟时病人脑电功率谱95％边缘频率（SEF）、中心频率（MPF）和δ比率（δR）的变化以及双谱指数（BI）变化。结果:静脉普鲁卡因复合阶段病人的SEF、MPF、BI值分别为15.46±1.87Hz、7.21±2.01Hz、68.77±7.99,明显低于两次单纯使用异丙酚时的结果（第1次分别为21.36±2.79Hz、11.55±2.62Hz、85.6±8.84,第2次分别为20.59±3.10Hz、9.5±3.44Hz、84.97±8.71）,而普鲁卡因复合阶段的δR值为88.41％±50.91％,较两次单纯异丙酚静滴大（第1、2次分别为45.66％±27.4％、46.48％±24.27％）。结论:静脉点滴普鲁卡因可以加强静脉异丙酚的麻醉作用。更多还原

【Abstract】 Objective: To study the effects ot intravenous 1％ procaine on cortex. Method: Ten patients,aged 29-59 years,for elective surgical operations,were observed the changes of spectral edge frequency（SEF）, medium power frequency （MPF）and δ rate（δR）on power spectral analysis and bispectral index（Bl）on bispectral analysis during intravenous propofol 4 mg·kg^-1· h^-1 purely for 15 min,intravenous combination of 1％ procaine 1mg·kg^-1·min^-1 and propofol for 30 min, then intravenous propofol 4mg·kg^-1·h^-1purely for 15min. Result: SEF,MPF and BI values during combination stage were lower significantly （15.46±1.87Hz, 7.21±2.01Hz, 68.77±7.99 respectively）than the values during other two stages（stage 1 and stage 2 were 21.36±2.79Hz,11.55±2.62Hz,85.6±8.84 and 20.59±3.10Hz, 9.5±3.44Hz, 84.97±8.71 respectively, P<0.05 ） while δR was higher in combination stage （88. 41％±50.91％）than the value in other two stages （stage 1 and 2 were 45.66％±27.4％ and 46.48％±24.27％ respectively,P<0.05）. Conclusion: Intravenous procaine might enhance the anesthetic effect of propofol.更多还原