【摘要】 为了进一步探讨精索静脉曲张（ＶＣ）与不育症的关系，对２２例正常人，３５例左侧ＶＣ患者行远红外阴囊测温及血清抗精子抗体（ＡｓＡｂ）测定，及睾丸组织免疫组化染色检测三种ＡｓＡｂ（ＩｇＭ、ＩｇＧ、ＩｇＡ）含量。结果发现：精液异常ＶＣ患者睾丸温度显著升高（Ｐ＜０００１），睾丸温度与静脉曲张程度无关，而与精子总数、活动率呈显著负相关（Ｐ＜００１）；ＶＣ患者血清ＡｓＡｂ阳性率５７％，显著高于正常人（Ｐ＜００２５）；睾丸ＩｇＭ阳性率５３％，ＩｇＧ７３％，均显著高于正常人。ＩｇＭ、ＩｇＧ含量与睾丸温度呈显著正相关（（Ｐ＜００１，Ｐ＜００４）。其中ＩｇＭ含量与睾丸生精功能呈显著负相关（Ｐ＜００１）。病理检查发现Ｓｅｒｔｏｌｉ细胞变性。认为ＶＣ患者同时存在睾丸温度升高及抗精子免疫反应，共同损害生精功能，睾丸温度升高使Ｓｅｒｔｏｌｉ细胞变性，破坏血睾屏障导致自身免疫反应发生。更多还原

【Abstract】 Scrotal temperature and antispermatozoal antibody (AsAb) were measured in 22 normal men and 35 left varicocele patients.The immunolocalization of AsAb( IgM,IgG,IgA) was studied in the testicular tissue of 15 normal men and 15 varicocele patients with immunohistochemistry.The testicular temperature of varicocele patients with poor semen was significantly higher than those of normal men (P<0001).There was no correlation between the testicular temperature and the degree of varicocele.There was negative correlation between testicular temperature and sperm count or sperm motility (P<001).The positive rate of serum AsAb in varicocele patients was 57%,significantly higher than that in normal men (P<0025).The positive rates of IgM and IgG in testicular tissue of varicocele patients were 53% and 73% respectively,being significantly higher than those of normal men (P<005,P<001).There was positive correlation between testicular temperature and the content of IgM or IgG (P<001,P<004),and the content of IgM was related to impaired spermatogenesis.Degeneration of sertoli cells was observed on testicular biopsy.The result suggests that testicular hyperthermia leads to the disruption of the blood testis barrier which is a prerequisite for AsAb formation.The testicular hyperthermia and the antisperm immunologic response are related to infertility.更多还原