【摘要】 通过前瞻性随机对照研究，检验心痛定是否对冲击波引起的急性肾功能损伤有保护作用。２７例接受ＥＳＷＬ的肾结石病人被随机分为两组：对照组１２例；心痛定组１５例，术前夜开始口服心痛定１０ｍｇ，一日３次，连用３天。放免法检测术前、后尿中白蛋白（ＡＬＢ）、ＩｇＧ、β２微球蛋白（β２ＭＧ）和ＴａｍｍＨｏｒｓｆａｌ蛋白（ＴＨＰ）２４小时总排泄量。结果显示：两组术后尿ＡＬＢ、ＩｇＧ水平均显著升高（Ｐ＜００１），β２ＭＧ和ＴＨＰ仅轻度升高和降低，两组比较无显著性差异（Ｐ＞０１，Ｐ＞００５）。认为冲击波对肾小球损伤是明显的，心痛定并不能减少蛋白排泄的增加。更多还原

【Abstract】 cases of renal stone underwent anaesthesia free ESWL were randomly assigned into 2 groups,the nifedipine group ( n =15) and the control ( n =12).For the former group,nifedipine was given orally,10mg 3 times a day for 3 succesive days beginning on the night before ESWL while the controls received no medication.Urinary albumin,immunoglobulin G,β 2 microglobulin and Tamm Horsfall protein were assayed to evaluate the renal function.A significant increase of urinary albumin ( P <0.01) and IgG ( P <0.001) was observed after ESWL while there was no significant change in β 2 MG and THP.There was no significant difference of these findings between the 2 groups and therefore it was concluded that nifedipine has no protective effect on renal damage induced by ESWL.更多还原