【摘要】 为研究精神分裂症患者血清中催乳素（ＰＲＬ）、生长激素（ＧＨ）的基础水平与正常人的差异，及精神分裂症患者治疗前后ＰＲＬ、ＧＨ水平的变化，以及与临床疗效的关系，采用放射免疫法，测定２０例精神分裂症患者治疗前和治疗后第２，４，６，８周末的ＰＲＬ、ＧＨ水平，并与１０名正常人对照，同时进行治疗前和治疗后第２，４，８周末简明精神病评定量表（ＢＰＲＳ）的评定。结果显示：精神分裂症患者的基础ＰＲＬ水平较正常对照组低，而ＧＨ水平较高，但无统计学意义；用抗精神病药治疗后ＰＲＬ升高，ＧＨ下降，ＰＲＬ水平的升高与ＢＰＲＳ减分值明显相关，支持精神分裂症的多巴胺功能亢进的假说。提示ＰＲＬ对治疗的反应可能是预测临床疗效的一个指标。更多还原

【Abstract】 The purpose of the study was to compare the differences of serum prolactin (PRL), growth hormone (GH) concentrations between schizophrenic patients and normal controls, the changes of serum PRL, GH before and after treatment, and relationships between the changes of hormones and the clinical effectiveness in the patients. 20 schizophrenics and 10 normal controls were included in the trial. Blood samples were taken before treatment and at the end of 2nd, 4th, 6th and 8th week after treatment, and the clinical symptoms were assessed with Brief Psychiatric Rating Scale (BPRS) at same time. The serum PRL and GH were measured by radioimmunoassay. The slight but not significant lower basal PRL and higher basal GH levels were observed in schizophrenic patients, compared with the controls, PRL level increased and GH level decreased after treatment. And the increase of PRL level was significantly correlated with the reduced score of BPRS. The results support the hypothesis of dopamine hyperactivity of schizophrenia and suggest the response of PRL to neuroleptic treatment might predict the therapeutic effectiveness.更多还原