【摘要】 目的:观察无淋巴结转移的贲门癌患者手术前后血液流变性的改变,并以氧自由基清除剂茶多酚作为工具药,探讨这些变化的发生机制。方法:用NXE-4锥板式粘度计测定全血表观粘度和血浆粘度,用常规方法测纤维蛋白原含量（Fg）和血细胞压积（HCT）,计算红细胞聚集指数（RAI）;结果:患者术前全血表观粘度值在切变率为200 s^-1、100 s^-1、40 s^-1、20 s^-1、10 s^-1、4 s¹时均显著高于正常对照组（P<0.01或P<0.05）;术后服药组在上述前四种切变率下显著低于术前,与正常对照组相近;在相同切变率下术后不服药组显著高于服药组,与术前数值相近;术后服药组血浆粘度也降低,纤维蛋白原含量在术前高于正常对照组,术后两组进一步增高;结论:无淋巴结转移的贲门癌患者存在明显的血液流变性异常,天然抗氧化剂茶多酚具有明显的防治效果,提示其发生机制可能与氧自由基的损伤作用有关。更多还原

【Abstract】 Objective: To observe changes of hemorheology before and after operation, and with aid of tea polyphenol as a scavenger of oxygen free radical, to explore the mechanism of the changes in the patients of cardiac cancer without lymphatic metastasis. Methods: NXE-4 hemoscosimeter was used to determine both apparent viscosity of whole blood （AVWB） and viscosity of plasma （VP）. Common techniques were adopted to measure contents of fibrinogen and hemotocrit. The erythrocyte aggregation index was calculated. Results: Before operation the patients AVWB at the shear rate of 200s^-1, 100s^-1, 40s^-1, 20s^-1, 10s^-1, 4s^-1 was all significantly higher than that of the normal control（P<0.01 or P<0.05）. While after operation, the AVWB in the drug administered group at the above shear rates significantly decreased in comparison with that before operation, but was similar to the control one. In the same shear rate, AVWB in none drug administered group after operation was significantly higher than that in drug administered group, but similar to that before operation. VP in drug administered group after operation was also decreased, fibrinogen content before operation was higher than the normal control group, but both groups were significantly increased after operation. Conclusion: Obvious abnormality of hemorheology exists in the patients of cardiac cancer without lymphatic metastasis. Natural oxygen agent, tea polyphenol shows dramatic curing effects. The mechanism of the changes is likely related to the injuring action of oxygen free radical.更多还原