【摘要】 目的：为了研究幽门螺杆菌（Hp）感染与胃癌及肠化类型的关系。方法：对胃癌高发区1333例普查人群的胃活检组织和30例胃癌手术标本病理切片做Warthin－starry染色，对慢性萎缩胃炎伴肠化生、慢性浅表胃炎伴肠化生、癌旁肠化生用粘液组化方法染色分型。结果：Hp感染与十二指肠球部溃疡高度相关，与胃溃疡、慢性浅表活动性胃炎、早期胃癌显著相关，与单纯萎缩性胃炎、萎缩胃炎伴肠化生、胃增生性息肉亦相关（P均＜0．05）；进展期胃癌的Hp感染率与慢性非活动性胃炎相比较，差异无显著性（P＞0．05）；各型胃癌中以腺癌Hp检出率高（75．4％），与粘液细胞癌Hp检出率（30％）相比较，差异有非常显著性（P＜0．01）。各型肠化生之间的Hp检出率比较，差异无显著性（P均＞0．05）。结论：Hp感染与胃癌有相关性。更多还原

【Abstract】 Objective: To investigate the relationship between H.pylori infection and gastric cancer. Methods: Warthin-Starry staining was carried out to detect H.pylori in 1333 gastric biopsy specimens and 30 surgical specimens of gastric cancer from the population of high risk area of gastric cancer; histological sections were stained with HID-ABpH2.5-PAS to identify the subtypes of intestinal metaplasia (subtype I a, I b, IIa, IIb). Results: The prevalence of H.pylori infection in 33 adolescents with chronic superficial gastritis(CSG) was 75.8％, compared to 75.9％ in 668 adults with CSG, no significant difference (P＞0.05)was seen. The H.pylori infection rates were 97.9％,86.8％. 82.2％, 81.6％, 81.3％, 76.3％,74.7％, 74.4 ％ respectively in groups of duodenal ulcer, gastric ulcer, chronic active superficial gastritis, superficial gastritis with intestinal metaplasia (IM), early gastric cancer, atrophic gastritis, atrophic gastritis with IM, gastric proliferative polyp correspondingly, Compared with non-active superficial gastritis group, these differences were statistically significant (P＜0.05). The infection rate in advanced non-cardia gastric cancer group (58.6％) was not significantly different from that (53.4％) in non-active superficial gastritis group (P＞0.05). The prevalence of H.pylori in adenocarcinoma group was 75.4 ％, significantly higher than 30％ in mucinous cell carcinoma group(P＜0.01). No significant differences were seen among the four subtypes of IM. According to the high infection rate of H.pylori in the group of early gastric cancer. It seems that H.pylori infection correlates highly with gastric cancer.更多还原